This Forum examines the elevated burden of blood cancers in Latino communities, exploring the genetic, metabolic, and systemic factors that contribute to higher incidence rates and disparate outcomes. Researchers present findings on why Hispanic/Latino children and adults experience acute lymphoblastic leukemia (ALL), a blood cancer, at rates 1.4-2x higher than non-Hispanic Whites, including inherited genetic differences more common in people with indigenous American ancestry and their role in disease susceptibility. The discussion addresses the complex interplay of genetic risk factors, obesity-related metabolic influences, and access barriers—from insurance challenges limiting stem cell transplants to communication gaps and trust issues affecting clinical trial participation among Latino families. We also heard from Blood Cancer United (formerly the Leukemia & Lymphoma Society) on their successful on-site and online programs, which reached 87,000 Spanish-speakers in 2024.