The Latino Cancer Institute (TLCI) is a nationwide community and research network dedicated to solving the issues and burden of Latino cancer.
Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs destructive immune reactions. Researchers have now discovered that NK cells can impair the effect of cancer therapies with immune checkpoint inhibitors (ICI) in this way. They could also be responsible for the rapid decline of therapeutic CAR-T cells. Interventions in this mechanism could potentially improve the efficacy of these cellular cancer immunotherapies.
St. Jude found 156 potential targets for chimeric antigen receptor (CAR) T--cell immunotherapy. Explore the discovery's promise to improve cancer therapies.
Scientists have discovered how glioblastoma evades the immune system by inducing pro-tumor macrophages via a glucose based epigenetic modification.
Working with human breast and lung cells, scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.
A new study provides compelling evidence that genome-matched treatments can provide significant patient benefit.
A new study has revealed an association between favorable survival outcomes for melanoma patients and the presence of higher populations of tissue-resident memory T cells (TRM). Data obtained from this study could be used not only for a TRM-based machine learning model with predictive powers for melanoma prognosis but could also elucidate the role TRM cells can play in the tumor immune microenvironment. This could guide the development of more effective and personalized anti-tumor immunotherapeutic treatment regimens for cancer patients.
Researchers are on a mission to kill drug-resistant bacteria, and a new study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.Researchers have shown that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.
A study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics. Scientists showed that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.
A team has identified a molecular cellular mechanism that is linked to microencephaly, a condition in which a baby's head is much smaller than expected.
Early detection has the potential to transform treatment and outcomes in cancer care, especially for cancers like liver cancer, which is typically diagnosed at a late stage with limited options for cure. A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer years before typical diagnosis.
An mRNA cancer vaccine quickly reprogrammed the immune system to attack the most aggressive type of brain tumor in a first-ever human clinical trial.
Researchers have found that cells inside clogged arteries have cancer-like properties that aggravate atherosclerosis, and anticancer drugs could be a new treatment.
A novel combination of two cancer drugs has shown great potential as a future treatment for patients with acute myeloid leukaemia (AML), one of the most common types of blood cancers. A new study has revealed the combination of two existing drugs eradicated AML cancer cells in lab-based tests. The discovery could soon lead to clinical trials.
A new study has found that pancreatic cancer cells are different based on their location in the pancreas, providing new information about tumors that could lead to better targeted treatments.
Scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney's filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments. The team improved the chemical cocktail for generating and growing NPCs in the laboratory, enabling the sustained growth of both mouse and human NPCs in a simple 2-dimensional format.
Researchers have identified a mechanism that can improve current immunotherapies by regulating cholesterol levels. The study shows the potential of manipulating cholesterol levels in future treatment strategies for cancer and other illnesses.
Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease. Atherosclerosis is characterized by a narrowing of arterial walls and can increase risk of coronary artery disease, stroke, peripheral artery disease, or kidney disorders. The findings could pave the way for the use of anti-cancer drugs to counteract the tumor-like mechanisms driving the buildup of plaque in the arteries, the major cause of cardiovascular disease.
A new study examining the role of aspirin in breast cancer treatment reveals critical issues related to health equity and aging that have broad implications for cancer and other disease intervention trials, say researchers.
A recently completed study indicates that circulatory protein levels can provide important information for increasingly accurate diagnoses and personalised care in patients with aggressive B-cell lymphoma. Researchers identified a specific protein profile linked to more severe disease.
Rates of breast cancer in women under the age of 50 are rising in Canada according to a study which showed an increase in breast cancer diagnoses among females in their twenties, thirties, and forties.
Adding a pre-ketone supplement -- a component of a high-fat, low-carb ketogenic diet -- to a type of cancer therapy in a laboratory setting was highly effective for treating prostate cancer, researchers found.
Researchers have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer.
Physical activity in natural environments prevent almost 13,000 cases of non-communicable diseases a year in England and save treatment costs of more than 100 million, new research has found.
Researchers discovered that more than 300 liver genes are under circadian control: Circadian variations affect how much of a drug is available and how effectively the body can break it down.
Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers have now uncovered for the first time how this exactly happens. The study provides rationales for new cancer immunotherapies and could make existing treatments more effective.
In a breakthrough for cancer research, scientists have created lab-grown mini-colons that can accurately mimic the development of colorectal tumors, offering a powerful new tool for studying and testing treatments for the disease.
Cleveland Clinic researchers developed an artficial intelligence (AI) model that can determine the best combination and timeline to use when prescribing drugs to treat a bacterial infection, based solely on how quickly the bacteria grow given certain perturbations. PNAS recently published their findings.
A new study has discovered how a lipid molecule found at high levels within tumors undermines the anti-cancer immune response and compromises a recently approved immunotherapy known as adoptive cell therapy (ACT) using tumor infiltrating lymphocytes, or TIL-ACT.
Researchers have published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas.
A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).
A study has sampled single live cancer cells and measured the fatty lipid compounds inside them. The team saw how those cells transformed in response to changes in their environment.
Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk.
A new study highlights the lasting financial impact of a cancer diagnosis for many working-age adults and their families in the United States. It shows a cancer diagnosis and the time required for its treatment can result in employment disruptions, loss of household income and loss of employment-based health insurance coverage, leading to financial hardship.
As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths. While the treatment options for this aggressive type of cancer remain limited, the incidence is increasing. A research team has now described a molecular signalling pathway that plays a key role in the development of liver cancer, thereby identifying a potential new starting point for the development of therapeutic treatments.
Plant-derived nanoparticles have demonstrated significant anticancer effects. Researchers recently developed rice bran-derived nanoparticles (rbNPs) that efficiently suppressed cell proliferation and induced programmed cell death of only cancer cells. Furthermore, rbNPs successfully suppressed the growth of tumors in mice having aggressive adenocarcinoma in their peritoneal cavity, without any adverse effects. Given their low production costs and high efficacy, rbNPs hold great promise for developing affordable and safe anticancer agents.
Scientists are developing and validating a patent-pending novel immunotherapy to be used against glioblastoma brain tumors. Glioblastomas are almost always lethal with a median survival time of 14 months. Traditional methods used against other cancers, like chemotherapy and immunotherapy, are often ineffective on glioblastoma.
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