Investigators have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results could help pinpoint treatment-resistant tumors.

Leveraging the power of AI and machine learning technologies, researchers developed a more effective model for predicting how patients with muscle-invasive bladder cancer will respond to chemotherapy. The model harnesses whole-slide tumor imaging data and gene expression analyses in a way that outperforms previous models using a single data type.

Researchers reveal critical mechanism behind idiopathic pulmonary fibrosis.

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer.

A research team has developed an innovative technique that enables precise modification of specific proteins within complex biological environments.

The body's cells respond to stress -- toxins, mutations, starvation or other assaults -- by pausing normal functions to focus on conserving energy, repairing damaged components and boosting defenses. If the stress is manageable, cells resume normal activity; if not, they self-destruct. Scientists have believed for decades this response happens as a linear chain of events: sensors in the cell 'sound an alarm' and modify a key protein, which then changes a second protein that slows or shuts down the cell's normal function. But researchers have now discovered a cell's response is more nuanced and compartmentalized -- not fixed or rigid, as previously thought.