The Latino Cancer Institute (TLCI) is a nationwide community and research network dedicated to solving the issues and burden of Latino cancer.
The protein galectin-1 (Gal-1) has been identified as a new PET imaging biomarker for immune checkpoint blockade (ICB) therapy, allowing physicians to predict the tumor responses before beginning treatment. Information garnered from Gal-1 PET imaging could also be used to facilitate patient stratification and optimize immunotherapy, enabling targeted interventions and improving patient outcomes.
Suddenly they appear and -- like the SARS-CoV-2 coronavirus -- can trigger major epidemics: Viruses that nobody had on their radar. They are not really new, but they have changed genetically. In particular, the exchange of genetic material between different virus species can lead to the sudden emergence of threatening pathogens with significantly altered characteristics.
Researchers have made a surprising new discovery in the structure of the centromere, a structure that is involved in ensuring that chromosomes are segregated properly when a cell divides. Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important implications for the process of chromosome segregation and provides new mechanisms underlying erroneous divisions in cancer cells. The research was published in Cell on May 13th 2024.
Men with prostate cancer could significantly reduce the chances of the disease worsening by eating more fruits, vegetables, nuts, and olive oil, according to new research.
An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study. The treatment, composed of nanoparticles fashioned from the cowpea mosaic virus -- a virus that infects black-eyed pea plants -- showed remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models, including colon, ovarian, melanoma and breast cancer.
Melanoma, an aggressive form of skin cancer that accounts for 75% of all skin-cancer-related deaths, is often detected later in people with darker skin complexions -- and the consequences can be devastating, a new study reveals.
Researchers have identified molecular and genetic pathways that direct the generation and maturation of parietal cells, the only cells in the body that produce acid, from stem cells. The findings can lead to new strategies to regulate parietal cell function in different diseases involving these cells, including autoimmune gastritis and stomach and esophageal cancers.
Scientists reveal how ETV4 controls stem cell differentiation in response to mechanical cues.
Researchers present Tripath: new, deep learning models that can use 3D pathology datasets to make clinical outcome predictions. The research team imaged curated prostate cancer specimens, using two 3D high-resolution imaging techniques. The models were then trained to predict prostate cancer recurrence risk on volumetric human tissue biopsies. By comprehensively capturing 3D morphologies from the entire tissue volume, Tripath performed better than pathologists and outperformed deep learning models that rely on 2D morphology and thin tissue slices.
Researchers have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors -- an advance that could transform cancer treatment. The promising findings involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells.
Investigators discovered that a subset of myeloid and lymphoid leukemias depend on a molecular complex called PI3Kgamma for survival. The study provides both mechanistic and preclinical evidence supporting the rapid initiation of clinical trials for patients with acute myeloid leukemia (AML) to test an existing medicine that inhibits the complex, called eganelisib, both alone and in combination with the most used AML chemotherapy, cytarabine.
Using artificial intelligence, scientists have developed a powerful predictive model for identifying the most potent cancer killing immune cells for use in cancer immunotherapies.
Recent reproductive research has opened the door for new treatments for solid cancer tumors, including breast cancer, lung cancer and melanoma.
For people with HIV, the risk of anal cancer varies according to their geographic region.
Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development. The fasting regime reduces the development of liver cancer in mice with pre-existing liver inflammation. The researchers identified two proteins in liver cells that are jointly responsible for the protective effect of fasting. An approved drug can partially mimic this effect.
Researchers used a breast cancer cell line panel and primary tumor explants from breast and cervical cancer patients to examine two different cellular contractility modes: one that generates collective tissue surface tension that keeps cell clusters compact and another, more directional, contractility that enables cells to pull themselves into the extracellular matrix. They found that more aggressive cells pull more strongly on the ECM than on themselves while noninvasive cells pull more strongly on themselves than on the ECM -- and that the different pulling behaviors are attributed to different structures of actin cytoskeleton inside the cells.
A new study shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.
Researchers have harnessed the technology behind foundation models, which power tools like ChatGPT, to discover new cancer imaging biomarkers that could transform how patterns are identified from radiological images. Improved identification of such patterns can greatly impact the early detection and treatment of cancer.
Researchers have unveiled a technology that promises to improve cancer treatment decisions based on a patient's biopsy. The pioneering biological research and development measures changes in immune system cells adjacent to cancer cells, providing crucial insights into the patient's immune response and potentially enhancing the effectiveness of immunotherapy.
The toll cancer takes on lives in the U.S. has declined during the last 28 years, but not equitably. Disparities persist in many historically marginalized communities -- including communities disadvantaged by race, socioeconomic status, orientation or gender identity, and geographic location -- despite community outreach and engagement programs designed to address them.
Researchers have developed a new AI tool to that generate new drug candidates for cancer, which could help streamline the typically laborious drug discovery process.
Researchers have found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered mechanical features and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, 'jump-starting' lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.
A team of scientists has developed a new AI software tool called 'BANKSY' that automatically recognizes the cell types present in a tissue, such as muscle cells, nerve cells and fat cells. Going a step beyond conventional AI tools which can group cells together into clusters if they contain similar molecules, BANKSY also considers how similar the cells' surroundings in the tissue are.
Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs destructive immune reactions. Researchers have now discovered that NK cells can impair the effect of cancer therapies with immune checkpoint inhibitors (ICI) in this way. They could also be responsible for the rapid decline of therapeutic CAR-T cells. Interventions in this mechanism could potentially improve the efficacy of these cellular cancer immunotherapies.
St. Jude found 156 potential targets for chimeric antigen receptor (CAR) T--cell immunotherapy. Explore the discovery's promise to improve cancer therapies.
Scientists have discovered how glioblastoma evades the immune system by inducing pro-tumor macrophages via a glucose based epigenetic modification.
Working with human breast and lung cells, scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.
A new study provides compelling evidence that genome-matched treatments can provide significant patient benefit.
A new study has revealed an association between favorable survival outcomes for melanoma patients and the presence of higher populations of tissue-resident memory T cells (TRM). Data obtained from this study could be used not only for a TRM-based machine learning model with predictive powers for melanoma prognosis but could also elucidate the role TRM cells can play in the tumor immune microenvironment. This could guide the development of more effective and personalized anti-tumor immunotherapeutic treatment regimens for cancer patients.
Researchers are on a mission to kill drug-resistant bacteria, and a new study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.Researchers have shown that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.
A study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics. Scientists showed that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.
A team has identified a molecular cellular mechanism that is linked to microencephaly, a condition in which a baby's head is much smaller than expected.
Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance.
Early detection has the potential to transform treatment and outcomes in cancer care, especially for cancers like liver cancer, which is typically diagnosed at a late stage with limited options for cure. A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer years before typical diagnosis.
An mRNA cancer vaccine quickly reprogrammed the immune system to attack the most aggressive type of brain tumor in a first-ever human clinical trial.
Researchers have found that cells inside clogged arteries have cancer-like properties that aggravate atherosclerosis, and anticancer drugs could be a new treatment.
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