Scientists have uncovered new details about the mechanism behind cancer progression. Researchers explored the influence the mechanical stiffening of the tumor cell's environment may have on the structure and function of the nucleus.

Combining bioinformatics and experimetal approaches, researchers have discovered replication hubs for human norovirus, the leading cause of viral gastroenteritis accounting for an estimated 685 million cases and approximately 212,000 deaths globally per year. The findings could lead to designing antiviral drugs to prevent, control or treat these serious infections.

Researchers have been able to identify at least three distinct subtypes of a rare type of bone cancer for the first time, which could transform clinical trials and patient care.

New findings point to an opportunity to improve therapies that use small RNAs to silence disease-causing genes, potentially including those involved in cancer.

Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new research.

A research team found out how AHCC, a standardized extract of cultured Lentinula edodes mycelia, might be able to suppress the progression of liver fibrosis.

There are several strategies for the early detection of prostate cancer. The first step is often a blood test for prostate-specific antigen (PSA). If PSA levels exceed a certain threshold, the next step typically involves taking a tissue sample for analysis. Another option is to use magnetic resonance imaging (MRI) to search for signs of a tumor before deciding whether a biopsy is necessary, reserving biopsies only for cases where abnormalities are detected. Researchers at conducted a study to determine whether this MRI-first approach is safe over the long term. Their findings show that this strategy poses no additional risk to patients for at least three years.

Until now, scientists have been unable to determine how metformin, a Type 2 diabetes medication that lowers blood sugar, works. A study provided direct evidence in mice that it reversibly cuts the cell's energy supply by interfering with mitochondria to lower glucose levels.

Research has uncovered a vulnerability in prostate cancer animal models that starves prostate tumors of critical nutrients and stunts their growth, which could lead to the development of new treatments for the deadly disease.

Tires and degrading garbage shed tiny pieces of plastic into the air, creating a form of air pollution that researchers suspect may be causing respiratory and other illnesses.

A team of researchers has created an innovative drug delivery system with outstanding potential to improve drug development.

Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer.

Researchers have revealed some of the precise mechanisms by which erroneous cells are recognized, marked for removal, and eliminated via apoptosis in developing zebrafish. Notably, they found that the protein Foxo3 may be a universal marker of cell competition in zebrafish and mice. These findings have important implications for congenital disorders, cancer, and aging, and may lead to novel treatments.

A new study explores whether cannabidiol (CBD), a component of marijuana, can reduce anxiety levels, specifically among patients with advanced breast cancer before a scan assessing tumor burden.

Medical researchers have announced the results of an innovative treatment approach that may offer improvement in overall survival in older patients with newly diagnosed glioblastoma while maintaining quality of life. Glioblastoma is the most lethal type of primary brain cancer due to its aggressive nature and its treatment-resistant characteristics. It is the most common form of primary brain cancer.

Researchers have discovered a process that breaks down mRNA molecules in the human body particularly efficiently. This could be useful, for example, in the treatment of cancer.

Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary. The tumor location often prevents necessary surgical intervention. Alternative pharmacological therapy requires an in-depth understanding of the tumor molecular characteristics. To address this gap, researchers analyzed gene expression within individual tumor cells. This study reports the molecular features and interactions of tumor and immune cells associated with two craniopharyngioma subtypes that will help identify future targeted therapeutics.

Scientists have developed a new blood test that could screen cancer patients to help make their treatment safer and more effective.

Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk -- in opposite directions -- for developing colon cancer. The link between these bile acids and colon cancer risk was recently uncovered as scientists sought to better understand the relationship between gut microbes and our bodies.

Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited efficacy. In a recent study, researchers investigated the potential of azolato-bridged dinuclear platinum(II) complexes, particularly 5-H-Y, as promising alternatives. Their findings highlight the complex's ability to inhibit AR signaling and induce cell death in prostate cancer cells, providing a new avenue for prostate cancer treatment.

An analysis of national data found that short-term mortality was not impacted for patients with advanced cancers during the shortage of the generic platinum chemotherapy drugs cisplatin and carboplatin that began in early 2023.

A new study offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that involves regular monitoring of the cancer without immediate intervention. Men on active surveillance who followed a low omega-6, high omega-3 diet with fish oil supplements had significantly lower levels of cancer cell proliferation after one year.

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective. Thus, finding ways to disarm that resistance and rejuvenate anti-cancer TILs so they can kill tumor cells is an important goal for cancer clinicians.

Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer cells. Typically, several molecules restrain the ability of T cells to target cancer cells and developing approaches to limit this restraining effect can lead to improved effectiveness of cancer immunotherapy. Research has now determined the structure of how an inhibitory molecule, LAG3, interacts with its main ligand and provides a new targeted approach to improving the effectiveness of immunotherapy for certain forms of cancer.

Researchers have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses. A better understanding of its structure may help optimize designs for the platform, which can be used to develop cancer treatments by either directly modifying immune cells or by creating proteins that help immune cells locate cancer cells.

A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.

Researchers are shining a light on cancer cells' energy centers -- literally -- to damage these power sources and trigger widespread cancer cell death. In a new study, scientists combined strategies to deliver energy-disrupting gene therapy using nanoparticles manufactured to zero in only on cancer cells. Experiments showed the targeted therapy is effective at shrinking glioblastoma brain tumors and aggressive breast cancer tumors in mice.

Analyses of self-tests for human papillomavirus (HPV) can be used to divide HPV-positive women into three risk groups, according to a new study. This method could be important for enhancing cervical cancer screening.

A new review reveals how your DNA shapes reproductive health, fertility, and even life expectancy.

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

Researchers have successfully developed a deep learning model that classifies pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, into molecular subtypes using histopathology images. This approach achieves high accuracy and offers a rapid, cost-effective alternative to current methods that rely on expensive molecular assays. The new study holds promise to advance personalized treatment strategies and improve patient outcomes.

The first study comparing surgery to active monitoring as treatment for ductal carcinoma in situ (DCIS) finds women who carefully monitor the precancerous cells are no more likely to develop breast cancer after two years than women who undergo surgery to remove them.

The future of breast cancer screening and risk-reducing strategies is being shaped by artificial intelligence (AI), according to a recent review article.

Researchers show that early-onset colorectal cancer (CRC) incidence rates are rising in 27 of 50 countries/territories worldwide, 20 of which have either exclusive or faster increases for early-onset disease. In 14 countries, including the United States, rates are increasing in young adults while stabilizing in those 50 years and older.

A new study found that a DNA sequencing test for advanced prostate cancer patients can distinguish between patients with poor and favorable prognoses.

A new study found that tumors grew 2.5 times larger in female fruit flies than males. With fruit flies sharing many genetic similarities and signaling pathways with humans, the finding could lead to better understanding of cancer development.